Skip to main content
. 2012 Feb 28;40(5):2345–2356. doi: 10.1093/nar/gkr970

Figure 3.

Figure 3.

Inhibition of nuclear receptor-mediated gene expression by β-aryl polyamides. (A) General schematic of nuclear receptor-mediated gene expression and polyamide inhibition of the protein–DNA interface. (B) Effect of β-turn polyamides 2 and 4 on DEX-induced GILZ gene expression as measured by qRT-PCR analysis. I = DEX-induced. NI = non-induced. Polyamide 2 concentrations: 100, 1000, 10 000 nM, polyamide 4 concentrations: 1, 10, 100 nM. (C) Effect of β-substituted polyamides 2 and 4 on dihydrotestosterone (DHT)-induced PSA gene expression as measured by qRT-PCR analysis. Polyamide 2 concentrations: 100, 1000, 10 000 nM, polyamide 4 concentrations: 1, 10, 100 nM. I = induced. NI = not induced.