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. 2012 Feb 28;40(5):2345–2356. doi: 10.1093/nar/gkr970

Figure 4.

Figure 4.

Time course analysis of polyamide-mediated inhibition of DEX-induced gene expression. (A) Effect of β-turn polyamides 2 and 4 on DEX-induced GILZ gene expression as measured by qRT-PCR analysis. I = DEX induced. NI = non-induced. Polyamide 2 concentration: 10 000 nM, polyamide 4 concentration: 100 nM. These concentrations of 2 and 4 were chosen because they show approximately equivalent inhibition of GR-mediated gene expression at 48 h. (B) Identical time course analysis of polyamide inhibition of FKBP5 gene expression over time.