Figure 10.

Model of Mph1 function on stalled replication forks arising from leading strand damage template and mode of Mph1 action in D-loop displacement. (A) A model describing the role of Mph1 in restarting stalled replication forks (see the text for detailed description). (B) Illustration of three representative D-loop substrates (5′-, 3′- or no-tailed) used previously (6). The arrows indicate the structure equivalent to flap structure that can be used for displacement of invaded strand (3′ or double flap as described).