Figure 3. Some mutations of αE175 give rise to currents showing heterogeneous kinetic properties.

A, example currents from αE175 mutant AChRs exhibiting heterogeneous kinetics. Three populations of current clusters are apparent in αE175C. B, R–E analysis of the αE175C populations shows that both the forward and backward gating rate constants change between populations. The spontaneous structural perturbation(s) that generates the heterogeneity has a Φ value of 0.62.