Table 1.

Φ and range energy values for loop 9

Residue	Φ(± SD)	Range energy (kcal mol−1)
αS173	—	0.9
αG174	0.82 ± 0.10	2.2
αE175	0.52 ± 0.06	2.1
αW176	0.85 ± 0.09	1.2
αV177	—	0.4
εE181	0.89 ± 0.10	2.5
εN182	0.78 ± 0.09	2.1
εG183	0.97 ± 0.08	1.3
εE184	0.80 ± 0.06	3.3

Φ is the slope of the rate–equilibrium plot (Figs 2 and 5). Range energy is the energy difference between the largest and smallest E₂ values for that residue. The range energies for αS173 and αV177 were too small to allow an estimation of Φ.