Figure 4. Bicuculline reduces GABA-independent binding of [35S]TBPS to recombinant α1β2γ2 receptors in a concentration-dependent manner.
Bicuculline caused a peak inhibition of GABA-independent binding of approximately 25%. Non-specific binding was determined in the presence of 100 μm picrotoxin. Data are represented as mean ± SEM % control binding of 4–10 independent experiments performed in triplicate. *P < 0.05 (one-way ANOVA with post hoc Tukey's test) compared to binding in the presence of 0.03 μm bicuculline.