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. 2011 Nov 7;590(Pt 1):209–221. doi: 10.1113/jphysiol.2011.222158

Figure 6. High fat diet increases the effect of ghrelin on the response of gastric (A and C) mucosal receptors.

Figure 6

A and C, the responses of gastric mucosal receptors to mucosal stroking with calibrated von Frey hairs (10–1000 mg) in the absence (•) and presence of ghrelin (1 (○), 3 (▪) and 10 nm (□)). These recordings were taken from mice fed a standard laboratory diet (Aa and Ca) or mice fed a high fat diet (Ab and Cb) for 12 weeks prior to the experiment. **P < 0.01 compared with control (•; ghrelin effect, two-way ANOVA). B, the effect of ghrelin on the response of mucosal receptors to stoking with a 50 mg von Frey hair in mice fed a SLD (•) and mice fed a HFD (○). Diet significantly enhanced the inhibitory action of ghrelin (**P < 0.01; diet effect, two-way ANOVA).