A and C, the responses of gastric mucosal receptors to mucosal stroking with calibrated von Frey hairs (10–1000 mg) in the absence (•) and presence of ghrelin (1 (○), 3 (▪) and 10 nm (□)). These recordings were taken from mice fed a standard laboratory diet (Aa and Ca) or mice fed a high fat diet (Ab and Cb) for 12 weeks prior to the experiment. **P < 0.01 compared with control (•; ghrelin effect, two-way ANOVA). B, the effect of ghrelin on the response of mucosal receptors to stoking with a 50 mg von Frey hair in mice fed a SLD (•) and mice fed a HFD (○). Diet significantly enhanced the inhibitory action of ghrelin (**P < 0.01; diet effect, two-way ANOVA).