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. Author manuscript; available in PMC: 2012 Mar 13.
Published in final edited form as: Neuropharmacology. 2011 Jul 5;61(5-6):924–936. doi: 10.1016/j.neuropharm.2011.06.021

Figure 3. Distinct NMDA receptors mediate the age-dependent effects of leptin.

Figure 3

Ai-Di, Plots of pooled and normalised data illustrating the effects of leptin on synaptic transmission in the presence of either ifenprodil (3 μM; filled circle) or NVP-AAM077 (0.1 μM; open circle) at P5-8 (Ai), P11-18 (Bi), 12-16 weeks (Ci) and 12-14 months of age (Di), respectively. Aii-Dii, Histograms of the pooled data showing the relative depressions in synaptic transmission induced by leptin in control conditions and in the presence of either ifenprodil or NVP-AAM077. At P5-8 and P11-18, blockade of NR2B subunits, prevented the synaptic depression induced by leptin. Conversely, the leptin-driven increase in synaptic transmission was significantly attenuated following blockade of NR2A subunits. In this and subsequent figures *, ** and *** represent P<0.05, P<0.01 and P<0.001, respectively.