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. Author manuscript; available in PMC: 2012 Mar 13.
Published in final edited form as: Neuropharmacology. 2011 Jul 5;61(5-6):924–936. doi: 10.1016/j.neuropharm.2011.06.021

Figure 7. Similar expression mechanisms underlie leptin induced long-term depression and de novo hippocampal LTD.

Figure 7

A. Low frequency stimulation (LFS)-induced LTD occludes leptin-induced LTD. Plot of the pooled data of the normalized EPSC amplitude against time in P5-8 slices. A LFS (1Hz for 900 sec) protocol was given to the test pathway (filled circle) at the time indicated by the bar, and this resulted in LTD of excitatory synaptic transmission. Subsequent addition of leptin (25 nM; 15 min) failed to induce any further inhibition of synaptic transmission in this path. In the control pathway (open circle), addition of leptin resulted in LTD and the magnitude of this depression was not significantly different to that obtained in the test pathway. B. Leptin-induced LTD occludes LFS-induced LTD. Application of leptin resulted in a persistent depression of synaptic transmission that was unaffected by the subsequent LFS protocol.