Figure 3.

Phylogenetic Analysis of EBNA1 and LMP1 protein sequences from EBV+DLBCL and EBV+DLBCL-PTLD. The phylogeny of EBV strains can be inferred from EBNA1 and LMP1 strain variation analysis, relative to the prototype type 1 strain B95 -8, the prototype type 2 strain AG876, and the type 1 strain GDI. With EB-NA1 (A), the tree had 4 main branches. For LMP1 (B), a five branch pylogenetic tree was made. The first large cluster in EBNA1 is separated into 3 clusters in the LMP1 phylogram because of the 30bp deletion in the C -terminus (not present in B95-8). The first (PDL4 and DL26) samples has no 30bp deletion, the second (PDL6, DL4, DL29 and DL82) has the 30bp deletion and the third (AG876, GDI) contains the deletion. DL: EBV+DLBCL and PDL: EBV+DLBCL-PTLD.