Table 2.

Recommended dose reductions according to age

Drug	65-75 years	> 75 years	Further reduction
Dexamethasone	40 mg/d d 1,8,15,22 every 4 wks	20 mg/d d 1,8,15,22 every 4 wks	10 mg/d d 1,8,15,22 every 4 wks
Melphalan	0.25 mg/kg or 9 mg/m2 d 1-4 every 4-6 wks	0.18 mg/kg or 7.5 mg/m2 d 1-4 every 4-6 wks	0.13 mg/kg or 5 mg/m2 d 1-4 every 4-6 wks
Thalidomide	100 mg/d	50 mg/d	50 mg qod
Lenalidomide (plus dexamethasone)	25 mg/d d 1-21 every 4 wks	15 mg/d d 1-21 every 4 wks	10 mg/d d 1-21 every 4 wks
Lenalidomide (plus melphalan-prednisone)	10 mg/d d 1-21 every 4 wks	5 mg/d d 1-21 every 4 wks	5 mg qod d 1-21 every 4 wks
Bortezomib	1.3 mg/m2 twice weekly d 1,4,8,11 every 3 wks	1.3 mg/m2 once weekly d 1,8,15,22 every 5 wks	1.0 mg/m2 once weekly d 1,8,15,22 every 5 wks
Prednisone	60 mg/m2 d 1-4	30 mg/m2 d 1-4	15 mg/m2 d 1-4
Cyclophosphamide	100 mg/d d1-21 every 4 wks	50 mg/d d 1-21 every 4 wks	50 mg qod d 1-21 every 4 wks

d, day; wk, week; qod, every other day