Figure 2.

Transcriptional regulation of granulocyte lineage commitment. The scheme displays a simplified overview of gene regulatory networks, which have a major influence on hematopoietic lineage choice during hematopoiesis. Supposed (dashed lines) and proved (continuous lines) cross-antagonisms between key transcription factors which function to regulate binary cell fate choices are noted in the scheme. Additionally, transcription factors that are important for the generation of particular intermediates are noted in white. HSC, hematopoietic stem cell; MPP, multipotent progenitor; LMPP, lymphoid-primed multipotent progenitor; CLP, common lymphoid progenitor; CMP, common myeloid progenitor; MEP, megakaryocyte-erythrocyte progenitor; GMP, granulocyte-macrophage progenitor; EoP, eosinophil progenitor; MDP, monocyte-dendritic cell progenitor; BMCP, basophil-mast cell progenitor; MCP, mast cell progenitor; BaP, basophil progenitor. Figure adapted from [15].