Table 2.

Stability of conventional and PEGylated vancomycin liposomes at the end of 1, 2 and 3 months.

Formulation	Test condition	Temp	% EE	Particle size (nm)	Physical appearance
Conventional liposomes	0 Mon		12.40	234 ± 92	Milky suspension
	1 Mon	4°C	11.71	258 ± 111	Milky suspension
		24°C	8.68	242 ± 97	Milky suspension; slight coagulation
		37°C	4.28	605 ± 800	Slightly dark color and thicker suspension, with growth of fungus on top, dispersed upon shaking.
	2 Mon	4°C	8.47	260 ± 85	Milky suspension
		24°C	5.01	305 ± 112	Slight dark color suspension with formation of big clumps of fungus, which are not dispersible upon shaking.
	3 Mon	4°C	8.23	250 ± 97	Milky suspension
		24°C	3.67	356 ± 43	Slight dark color suspension with formation of big clumps of fungus, which are not dispersible upon shaking
PEGylated liposomes	0 Mon		12.78	181 ± 82	Milky suspension
	1 Mon	4°C	11.17	202 ± 107	Milky suspension
		24°C	9.40	200 ± 106	Milky suspension; slight coagulation
		37°C	6.90	208 ± 109	Slightly dark color and thicker suspension, with growth of fungus on top, dispersed upon shaking.
	2 Mon	4°C	10.33	205 ± 93	Milky suspension
		24°C	5.29	355 ± 154	Slight dark color suspension with formation of big clumps of fungus, which are not dispersible upon shaking.
	3 Mon	4°C	9.89	210 ± 88	Milky suspension
		24°C	4.98	290 ± 120	Slight dark color suspension with formation of big clumps of fungus, which are not dispersible upon shaking