Table 1.
Volatiles released by Mycobacterium tuberculosis grown on a 7H11 solid medium.a
| Compound | I | strain 1 | strain 2 | strain 5 | strain 6 | H37Ra |
| 4-Hydroxy-4-methylpentan-2-one (14) | 847 | – – – b | – – – + c | – + – – – – – d | – – – e | – f |
| 4-Pentanolide (10) | 950 | + + + | + + + + | – – + + + + + | + + + | + |
| Methyl 2-furoate (15) | 978 | – – – | + + – + | – – + + – – – | + + – | + |
| 3-Methyl-4-pentanolide (16)g | 984 | – + + | + + + + | – – – – – – – | – – – | – |
| Unknown | 1006 | – – + | + – + – | – – + + + + + | – – + | – |
| Unknown | 1021 | + + – | + + – + | – – – – – – – | – – – | – |
| 4-Methylanisol (5) | 1021 | – – + | – – + – | – – + + + + + | – – + | – |
| Unknown | 1084 | – + + | + + + – | – – + + + + + | – + + | – |
| Methyl benzoate (8) | 1093 | + + + | + + + + | + + + + + + + | + + + | + |
| 2-Phenylethanolh | 1113 | + + + | + + + + | – + + + + + + | + + + | – |
| 4-Methyl-5-hexanolide (17)g | 1133 | – – – | – + + – | – – – – – – – | – – – | – |
| Methyl nicotinatec (3) | 1136 | + + + | + + + + | – + + + + + + | + + + | – |
| Ethyl benzoate (9) | 1169 | – – – | – – – – | – – – + + + + | – – – | + |
| Methyl phenylacetate (1) | 1177 | + + – | – + + + | – – – + + + + | + + + | – |
| Methyl salicylate (6) | 1193 | + – – | – – – – | – – + – – – + | – + – | + |
| Benzothiazole | 1222 | – – – | – – – + | – – – + – – – | – – – | – |
| Methyl 2-aminobenzoate (7) | 1341 | – – – | + + – – | – – – + – – – | – – – | – |
| Methyl p-anisate (2) | 1376 | + + + | + + + + | – + + + + + + | + + + | – |
| Ethyl p-anisate (18) | 1450 | – + – | + + – – | – + + + – + + | + + – | – |
| 2-Phenylanisol (4) | 1559 | + + + | + + + + | – + + + + + + | + + + | – |
aI: gas-chromatographic retention index on DB-5; +: compound detected in sample; –: compound not detected in sample. bThe results of three analyses are shown for each experiment performed on differently aged cultures: 25 days (d), 26 d, 32 d. cThe results of four analyses are shown for each experiment performed on differently aged cultures: 20 d, 22 d, 30 d, 33 d. dThe results of seven analyses are shown for each experiment performed on differently aged cultures: 4 d, 9 d, 18 d, 21 d, 28 d, 29 d, 48 d. eThe results of three analyses are shown for each experiment performed on differently aged cultures: 19 d, 23 d, 31 d. fThe results of an analysis on a 14 d old culture are shown. gMixture of both diastereomers; I of first eluting isomer is shown. hTraces present in the medium.