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. 2012 Feb 1;2012:360379. doi: 10.5402/2012/360379

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Copyright © 2012 Ana Luisa Gutierrez-Valdez et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mean latencies to cross two narrow beams (6 and 12 mm) (±SEM) before and after 6-OHDA lesion and during treatments. Note that from the beginning of LD treatment the rats improve their motor behavior until 21 days and afterwards showed a significant increase in the time to transverse the beam compared to controls. In contrast, the time to cross the beam of melatonin-treated rats until day 21th was similar to those animals with lesion and no treatment; afterwards the time was reduced drastically resembling the values of the control group ( ^∗ P < .001 versus control group; ^• P < .001 LD-treated group versus melatonin-treated group; ANOVA test).