Development in mean (±s.e.m.) body weight (a) and waist circumference (b) in the trans fat (TFA; n=24) and control (CTR; n=25) groups during the 16-week dietary intervention. Baseline values were not significantly different (unpaired t-test, P>0.05). Note that the y-axes have been truncated. In spite of the isocaloric study design, body weight increased significantly in both diet groups (P=0.002 for effect of time in repeated-measures analysis of covariance testing for interaction between diet group and time (weeks 4, 8, 12, 16) with week 0 as a covariate; there was no significant interaction between diet and time, nor effect on diet). Waist circumference tended to increase more in the TFA group (P=0.08 for effect of diet; there was no significant interaction between diet and time, nor effect of time).