Table 4. Blood lipids in the TFA (n=24) and control (n=25) groups and in lean reference subjects (n=19)a.

	Week 0b	Week 8	Week 16	ANCOVAc
				Ptime*diet	Pdiet	Ptime
Total cholesterol (mmol l−1)				0.16	0.03	0.88
TFA	5.44±0.19	6.07±0.21	5.95±0.19
Control	5.54±0.20	5.77±0.18	5.86±0.21
Lean reference subjects	5.46±0.18	NA	NA
HDL cholesterol (mmol l−1)				0.23	0.03	<0.001
TFA	1.54±0.06	1.54±0.05	1.38±0.04
Control	1.65±0.07	1.69±0.08	1.59±0.06
Lean reference subjects	1.69±0.05	NA	NA
LDL cholesterol (mmol l−1)				0.24	0.002	0.01
TFA	3.39±0.18	3.91±0.19	4.01±0.18
Control	3.36±0.20	3.46±0.16	3.72±0.19
Lean reference subjects	3.47±0.17	NA	NA
LDL/HDL-cholesterol ratio				0.23	<0.001	<0.001
TFA	2.31±0.16	2.64±0.17	3.02±0.20
Control	2.20±0.20	2.20±0.17	2.45±0.16
Lean reference subjects	2.08±0.11	NA	NA
Total/HDL-cholesterol ratio				0.22	<0.001	<0.001
TFA	3.65±0.19	4.08±0.22	4.45±0.23
Control	3.54±0.23	3.60±0.21	3.83±0.20
Lean reference subjects	3.25±0.12	NA	NA
Triglycerides (mmol l−1)d				0.78	0.39	0.09
TFA	1.13±0.10	1.39±0.15	1.24±0.09
Control	1.19±0.10	1.35±0.12	1.23±0.11
Lean reference subjects	0.67±0.04e	NA	NA

Abbreviations: ANCOVA, analysis of covariance; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NA, not applicable; TFA, trans fatty acid.

^aValues are means±s.e.m., completers only.

^bThere were no significant differences in baseline values between diet group (unpaired t-test, P>0.05).

^cP values were derived by repeated-measures analysis of covariance testing for interaction between diet group and time (week 8, 16) with week 0 as a covariate. P values for effects of diet and time, respectively, were derived from analyses omitting the interaction term.

^dANCOVA performed on log10-transformed values.

^eSignificantly different from overweight intervention subjects (diet groups combined) by unpaired t-test; P<0.05.