Table 2. Metabolic parameters of DS/lean and DS/obese rats at 18 weeks of age.
| Parameter | DS/lean | DS/obese | P |
|---|---|---|---|
| Leptin (ng ml−1) | 1.67±0.37 | 53.97±2.34 | 0.0005 |
| Glucose (mg per 100 ml) | 124.50±6.40 | 136.33±5.27 | 0.2864 |
| Insulin (ng ml−1) | 0.55±0.29 | 3.18±1.39 | 0.0209 |
| Triglyceride (mg per 100 ml) | 102.25±25.98 | 1559.93±353.89 | 0.0029 |
| Total cholesterol (mg per 100 ml) | 116.25±11.59 | 371.14±39.21 | 0.0029 |
| LDL-cholesterol (mg per 100 ml) | 24.00±2.94 | 73.85±7.15 | 0.0046 |
| HDL-cholesterol (mg per 100 ml) | 26.75±1.11 | 50.14±2.30 | 0.0029 |
| LDL-cholesterol/HDL-cholesterol | 0.89±009 | 1.59±0.15 | 0.0257 |
| AST (U l−1) | 57.00±1.52 | 67.33±4.67 | 0.1213 |
| ALT (U l−1) | 24.67±0.88 | 39.25±2.63 | 0.0087 |
| Blood urea nitrogen (mg per 100 ml) | 19.98±1.86 | 76.21±13.56 | 0.0029 |
| Creatinine (mg per 100 ml) | 0.32±0.03 | 1.09±0.19 | 0.0029 |
| Urinary protein (mg day−1) | 336.29±19.58 | 735.52±93.97 | 0.0143 |
| Ccr (ml min–1 per g kidney weight) | 1.25±0.12 | 0.20±0.03 | 0.0082 |
| Ccr (ml min–1 per 100 g body weight) | 0.91±0.06 | 0.18±0.02 | 0.0082 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; Ccr, creatinine clearance; DS, Dahl salt-sensitive; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
Analytes were measured in serum unless indicated otherwise. Data are given as means±s.e.m. for surviving animals (n=6 and 7 for DS/lean and DS/obese rats, respectively).