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Expression of tissue remodeling factors is impaired in mice deficient in MD-2 and TLR4. The livers of MCD and MCS diet-fed genotype controls and MD-2 KO and TLR4 KO mice were analyzed for matrix metalloproteinase (MMP)-2 and tissue inhibitor of metalloproteinase (TIMP)-1 expression by qPCR using specific primers and normalization against the housekeeping gene 18S; data are shown as means ± SE from n = 6–16/group; *P < 0.05 compared with the corresponding MCS group.
