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Rat model of TAC. The relationship between apoptosis and the left ventricle (LV)/body wt (BW) is shown for total cells (A), in subendocardium (B), and in subepicardium (C). All of these correlations were very significant (R2 and P values for regressions are shown). In contrast, there was no significant relationship between the amount of apoptosis and LV ejection fraction (EF, %) (D), i.e., LV EF (%) did not decline with increasing amounts of apoptosis with chronic severe LVH.
