. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: Int J Tuberc Lung Dis. 2012 Jan;16(1):90–97. doi: 10.5588/ijtld.11.0153

Table 2.

Characteristics Associated with Mortality in Patients with Multidrug-resistant Tuberculosis (MDR-TB)

	Unadjusted Analysis		Multivariate Analysis
Variables	Hazard Ratio	p-value	Hazard Ratio	p-value
Female sex	0.77	0.26	1.15	0.73
Positive sputum smear	1.99	0.009	2.10^*	0.08^*
DST: Resistance to HR^†	Ref	Ref	Ref	Ref
Resistance to HRS^‡	1.98	0.008	2.45^∥	0.07^∥
Resistance to HRES^§	1.11	0.77	1.55^¶	0.53^¶
CD4 cell count: <50 cells/mm³	1.27	0.53	4.64	0.01
51-200 cells/mm³	2.10	0.03	4.17	0.008
>200 cells/mm³	Ref	Ref	Ref	Ref
Received ART (time dependent)	0.86	0.63	0.67	0.35
Extrapulmonary MDR-TB	2.02	0.003	1.39^#	0.42^#
Hospitalization within past year	1.80	0.01	1.12	0.78

H: isoniazid; R: rifampin; E: ethambutol; S: streptomycin; Cx: ciprofloxacin; Km: kanamycin

Bold denotes p-value<0.05

Positive sputum smear: HR=2.54, p=0.002: in multivariable model following imputation

^†

Includes one patient with HRCx resistance pattern

^‡

Includes one patient with HRSCx and one patient with HRSKm resistance patterns

^§

Includes two patients with HRESCx resistance pattern

^∥

Resistance to HRS: HR=2.53, p=0.01: in multivariable model following imputation

^¶

Resistance to HRES: HR=2.97, p=0.02: in multivariable model following imputation

Extrapulmonary TB: HR=1.75, p=0.04: in multivariable model following imputation