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. 2012 Mar 12;209(3):471–478. doi: 10.1084/jem.20112401

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© 2012 Odumade et al.

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Figure 1. — Extensive CD8⁺ T cell activation and expansion occur during primary EBV infection. PBMCs from each subject were stained with antibodies against CD3, CD4, CD8, CD38, CD45RA, DR, and GrzmB. Panels A–C show sample flow cytometric analysis from subject 5036 before, during, and after acute infection with EBV. d, day relative to symptom onset. (A) CD4 and CD8 expression on CD3⁺ T cells over time. (B and C) Dot plots showing activation markers CD38, HLA-DR (DR), or GrzmB expression on total CD3⁺CD8⁺ T cells (B) or total CD3⁺CD4⁺ T cells (C). (D and E) The frequency (D) or number (E) of CD8⁺ or CD4⁺ T cells before (Pre-IM), during (At IM), and after (Post-IM) acute primary EBV infection (infectious mononucleosis) is shown. Wilcoxon signed rank test, P < 0.05 considered statistically significant (n = 14). Horizontal bars indicate the mean.