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. 2012 Mar 12;209(3):507–520. doi: 10.1084/jem.20111424

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© 2012 Hamerlik et al.

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Figure 1. — VEGFR2 is enriched on the surface of human GSCs. (A) Graph of cell surface VEGFR2⁺ cell fractions among CD133⁺ versus CD133⁻ GBM cells based upon FACS analysis of 17 freshly dissociated human glioma specimens (**, P = 0.0017). (B) Immunohistochemical detection of VEGFR2 in clinical GBM specimens (left and middle image) of both surface (arrowhead) and intracellular (arrow; cytosolic) VEGFR2; normal brain (NB; right) shows VEGFR2 in endothelial cells/vessels (*). Bar, 50 µm. (C) Graph of surface and cytosolic VEGFR2 in 4 GBM (two independent experiments). (D) Representative plots of FACS-analyzed surface (mem) versus cytosolic (cyto) VEGFR2 in CD133⁺ and CD133⁻ GBM cells (specimens T4121 and T3691).