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. 2012 Mar;86(5):2856–2858. doi: 10.1128/JVI.06882-11

Fig 3.

Fig 3

Receptor binding by alpha-coronavirus NL63-CoV and beta-coronavirus SARS-CoV C-domains. (A) Crystal structure of NL63-CoV C-domain complexed with human ACE2 (PDB identification no. 3KBH). (B) Crystal structure of SARS-CoV C-domain complexed with human ACE2 (PDB identification no. 2AJF). (C) A hydrophobic tunnel structure at the NL63-CoV/ACE2 interface, comprising residues Tyr41 and Asp37 from ACE2 and Ser535 and Tyr498 from the NL63-CoV C-domain. (D) A hydrophobic tunnel structure at the SARS-CoV/ACE2 interface, comprising residues Tyr41 and Asp37 from ACE2 and Thr487 and Tyr491 from the SARS-CoV C-domain. The hydrophobic tunnels in panels C and D bury a salt bridge between Lys353 and Asp38 from ACE2. ACE2, angiotensin-converting enzyme 2; VBM, virus-binding motif.