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Diagram of VZV TK. Mutations that confer drug resistance located in the ATP-binding site, the nucleoside-binding site, and Leu332 are shown in dark shaded boxes. Mutations found in other conserved regions of the viral TK are shown in lightly shaded boxes, while mutations located in nonconserved regions of the viral enzyme are shown in open boxes. Mutations found in the present study are underlined.
