Table 1.
Genotypic characterization of drug-resistant VZV mutants obtained in vitro under selective pressure with ACV, BVDU, BVaraU, and the BCNAs
| Resistance selection under pressure with: | No. of clones/total | Changes in viral TK associated with drug resistance |
|
|---|---|---|---|
| Nucleotide | Amino acid | ||
| BVDU | 6/6 | 574-G to T | E192-stop |
| BVaraU | 6/7 | 493–498 C insertion | Frameshift |
| 1/7 | 641-T deletion | Frameshift | |
| ACV-A | 2/4 | 493–498 C deletion | Frameshift |
| 1/4 | 256-A to G | T86A | |
| 493–498 C deletion | Frameshift | ||
| 1/4 | 493–498 C insertion | Frameshift | |
| ACV-B | 4/4 | 493–498 C insertion | Frameshift |
| ACV-C | 4/4 | 493–498 C deletion | Frameshift |
| ACV-E | 1/4 | 493–498 C insertion | Frameshift |
| 3/4 | 256-A to G | T86A | |
| 493–498 C insertion | Frameshift | ||
| PCV | 4/4 | None | None |
| Cf1603 | 6/6 | 493–498 C insertion | Frameshift |
| Cf1368 | 3/5 | 412 insert TA | Frameshift |
| 2/5 | 70-G to A | G24R | |
| Cf1742 | 8/8 | 493–498 C insertion | Frameshift |
| Cf1743 | 17/19 | 493–498 C insertion | Frameshift |
| 2/19 | 256-A to G | T86A | |
| 493–498 C insertion | Frameshift | ||