Fig 3.

14G7 Fab-GP interactions. (A) Hydrogen bonds between the type I β turn of GP and the antibody. Four hydrogen bonds shown here include (i) the main-chain N of Ile-482 to the carbonyl O of Asp-31 of the heavy chain, (ii) a side chain N of Asn-484 to a side chain O of Asp-101 of the heavy chain, (iii) the side chain O of Thr-485 to the carbonyl O of Ala-99 of the heavy chain, and (iv) the carbonyl O of Thr-485 to the imidazole ring of His-38 of the light chain. (B) Hydrogen bond between the type I and IV β turns (the carbonyl O of Gly-488 to Arg-100 of the light chain) and another formed by a residue in the type IV β turn (the main-chain N of Ala-490 to a side chain O of Glu-50 of the heavy chain). Hydrogen bonds are indicated as dashed lines. See Table 2 for a complete list of the corresponding contacts. For clarity, panels A and B are shown in different orientations from that of Fig. 2.