Fig 5.

Multiple sequence alignment of the 14G7 Ebola virus epitope performed using CLUSTAL W. Gly-480 and Thr-485 (boldface red text) are completely conserved across the five species of the Ebolavirus genus. Of these two, Thr-485 is critical for 14G7 binding. The portion of the sequence visualized in the crystal structure is marked by a bracket. The residues that comprise the most significant region of interaction are marked by asterisks and are also important for antibody contact. Zaire denotes Ebola virus (formerly known as Zaire ebolavirus).