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Models of cellular entry of iridoviruses. (A) Naked frog virus 3 (FV3) enters BHK-21 cells via membrane fusion. (B) Enveloped FV3 particles enter BHK-21 cells via clathrin-dependent endocytosis. Viruses internalize into BHK-21 cells by adsorptive endocytosis via coated pits and then appear to move through endosomes and, ultimately, to lysosomes. (C and D) Tiger frog virus (TFV) (C) and infectious spleen and kidney necrosis virus (ISKNV) (D) internalize into their host cells via caveolae.
