Table 1.

Sampling intervals for the IND-directed toxicology study of PVS-RIPO

Procedure	Study day
	–7	0	3	7	10	12	14	15	18	21	25	28	35	43	49	56
Virus injection		x
Body wt	x	x	x	x	x		x			x		x	x	x	x	x
Temp	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x	x
Blood collection	x	x	x		x		x			x		x		x		x
Clinical chemistry/hematology	x	x	x		x		x			x		x		x		x
Serum (α-PV ab)		x	x		x							x				x
Serum (viremia)		x	x		x		x					x				x
Saliva		x					x					x		x		x
Urine		x					x					x		x		x
Stool			x		x	x	x	x	x	x	x	x	x	x	x	x
Ophthalmic exam	x						x					x		x		x
Complete physical			x		x											x
Necropsy			x		x											x