Ultrastructural analyses of macrophage internal HIV-1 accumulations. Serial sections 3, 4, and 5 and the slice corresponding to the other Gag accumulation present in the same macrophage (compare Fig. 6 and Fig. S4 in the supplemental material) were magnified to identify ultrastructural features of the sites of Gag accumulation. Some viral particles are marked with red arrows. CCV, clathrin-coated vesicle; L, lysosome; MT, mitochondria; rER, rough endoplasmic reticulum; VCC, virus-containing compartment; W, membranous web. The scale bar indicates a distance of 500 nm.