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Sera from gp140-immunized animals recognize native trimers. The binding of representative sera from each group to native JR-FL Env trimers (A) and JR-FL D368R mutant trimers (B) was examined. nAbs b12 and 2F5 and nonneutralizing antibody 15e served as controls. A quantitative evaluation of the trimer band intensity is presented in the bar graphs, where small bars represent efficient trimer binding of the sera and a resulting decrease in the intensity of the trimer band.
