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(A) Schematic of Hendra virus F protein and the HRB and TMD amino acid sequences. FP, fusion peptide; HR, heptad repeat; TMD transmembrane domain; CT, cytoplasmic tail; S-S, disulfide bond. (B) Helical wheel representation of the Hendra virus F TMD. Residues at positions a and d of the helical wheel, denoted by stars, are hypothesized to form the interface of the three TMD helices.
