Fig 3.

Randomly associating residue positions does not generate networks similar to the viral covariance networks. (A) Networks generated from covariances in a control hepatitis C virus alignment of 300 sequences in which residues at positions of variance were scrambled. (B) Network and degree distribution plot generated from 3,199 randomly linked positions to mimic the number of edges in the alignment of 100 HCV 1a sequences. (C) Network and degree distribution plot generated from 208 randomly linked positions to mimic the number of edges in the alignment of 41 HEV sequences.