Fig 7.

Regions of the HBV reverse transcriptase domain that covary with both the terminal protein and RNase H domains. Residues in the HBV polymerase reverse transcriptase domain model that covary with terminal protein (top) or RNase H (bottom) domain residues for HBV genotype D are in black. Regions of the model in which covariance is found for all three genotypes with both the terminal protein and RNase H domains are circled. The “thumb” region of the model is at the upper left, and the “finger” region is at the upper right. The darker gray is DNA modeled into the active-site groove.