FIGURE 1.

Mean (±SEM) cholesterol absorption as measured by area under the [¹³C]cholesterol red blood cell enrichment curve over 72 h after ingestion of 75 mg [3,4-¹³C]cholesterol in response to consumption of plant sterols compared with placebo capsules in phytosterolemia heterozygotes and control cohorts (A), the percentage change in cholesterol absorption between treatments within group (B), the fractional synthesis rate of cholesterol measured at 24 h by deuterium incorporation after deuterium oxide consumption (C), and the percentage change in cholesterol synthesis between treatments within group (D). Differences between groups and treatments were assessed by repeated-measures 2-factor ANOVA; *P < 0.05 indicates a significant difference between treatments within group. A: P-interaction = 0.732. C: P-interaction = 0.904. CON, control group (n = 15); HET, phytosterolemia heterozygote group (n = 10); RBCs, red blood cells.