TABLE 2.
Baseline characteristics of the study participants at the time of screening
| Variable | All subjects (n = 25) | Heterozygotes (n = 10) | Control subjects (n = 15) | P value1 |
| Age (y) | 33.6 ± 2.22 | 33.3 ± 4.0 | 33.8 ± 2.6 | 0.914 |
| Sex | ||||
| Male | 12 | 4 | 8 | |
| Female | 13 | 6 | 7 | |
| Body weight (kg) | 83.4 ± 4.1 | 79.0 ± 4.7 | 86.3 ± 6.1 | 0.395 |
| BMI (kg/m2) | 29.9 ± 1.1 | 29.1 ± 1.1 | 30.4 ± 1.7 | 0.578 |
| Total cholesterol (mmol/L) | 5.49 ± 0.15 | 5.32 ± 0.27 | 5.61 ± 0.16 | 0.336 |
| LDL cholesterol (mmol/L) | 3.30 ± 0.11 | 3.28 ± 0.22 | 3.31 ± 0.12 | 0.886 |
| HDL cholesterol (mmol/L) | 1.23 ± 0.06 | 1.35 ± 0.10 | 1.15 ± 0.06 | 0.102 |
| Triglycerides (mmol/L) | 2.26 ± 0.30 | 1.53 ± 0.22 | 2.74 ± 0.45 | 0.048 |
| β-Sitosterol (μmol/L) | 9.42 ± 0.86 | 11.63 ± 1.71 | 7.95 ± 0.70 | 0.033 |
| Campesterol (μmol/L) | 14.16 ± 1.20 | 18.18 ± 1.99 | 11.49 ± 1.06 | 0.004 |
| Lathosterol (μmol/L) | 10.42 ± 0.83 | 8.88 ± 0.85 | 11.40 ± 1.15 | 0.123 |
1
Differences between groups (heterozygotes and control subjects) were assessed by 1-factor ANOVA; P < 0.05 indicates significance.
2
Mean ± SEM (all such values).