TABLE 3.
Characteristics of biopsy specimens
| Children 9–13 y old (n = 114) | Males ≥14 y old (n = 240) | Premenopausal women ≥19 y old (n = 116) | Postmenopausal women (n = 194) | |
| Steatosis grade [n (%)] | ||||
| <5% | 2 (1.8) | 10 (4.2) | 4 (3.5) | 9 (4.6) |
| 5–33% | 26 (22.8) | 85 (35.4) | 36 (31.0) | 78 (40.2) |
| >33–66% | 38 (33.3) | 83 (34.6) | 39 (33.6) | 61 (31.4) |
| >66% | 48 (42.1) | 62 (25.8) | 37 (31.9) | 46 (23.7) |
| Lobular inflammation [n (%)] | ||||
| <2, <20× magnification | 58 (50.9) | 132 (55.0) | 54 (46.6) | 94 (48.5) |
| 2–4, <20× magnification | 53 (46.5) | 93 (38.8) | 43 (37.1) | 77 (39.7) |
| >4, <20× magnification | 3 (2.6) | 15 (6.3) | 19 (16.4) | 23 (11.9) |
| Ballooning [n (%)] | ||||
| None | 51 (44.7) | 93 (38.8) | 33 (28.5) | 52 (26.8) |
| Few | 39 (34.2) | 83 (34.6) | 32 (27.6) | 45 (23.2) |
| Many | 24 (21.1) | 64 (26.7) | 51 (44.0) | 97 (50.0) |
| NAFLD1 activity score [n (%)] | ||||
| 1 | 1 (0.9) | 4 (1.7) | 1 (0.9) | 3 (1.6) |
| 2 | 7 (6.1) | 32 (13.3) | 12 (10.3) | 23 (11.9) |
| 3 | 23 (20.2) | 47 (19.6) | 21 (18.1) | 22 (11.3) |
| 4 | 29 (25.4) | 56 (23.3) | 16 (13.8) | 41 (21.1) |
| 5 | 27 (23.7) | 52 (21.7) | 24 (20.7) | 45 (23.2) |
| 6 | 18 (15.8) | 28 (11.7) | 17 (14.7) | 36 (18.6) |
| 7 | 9 (7.9) | 18 (7.5) | 18 (15.5) | 18 (9.3) |
| 8 | 0 (0.0) | 3 (1.3) | 7 (6.0) | 6 (3.1) |
| Fibrosis stage [n (%)] | ||||
| 0 (none) | 27 (23.9) | 78 (32.5) | 34 (29.6) | 40 (20.7) |
| 1a (mild, zone 3, perisinusoidal) | 7 (6.2) | 42 (17.5) | 19 (16.5) | 20 (10.4) |
| 1b (moderate, zone 3, perisinusoidal) | 1 (0.9) | 26 (10.8) | 18 (15.7) | 20 (10.4) |
| 1c (portal/periportal only) | 38 (33.6) | 9 (3.8) | 3 (2.6) | 5 (2.6) |
| 2 (zone 3 and periportal, any combination) | 22 (19.5) | 45 (18.0.8) | 26 (22.6) | 38 (19.7) |
| 3 (bridging) | 17 (15.0) | 28 (11.7) | 13 (11.3) | 46 (23.8) |
| 4 (cirrhosis) | 1 (0.9) | 12 (5.0) | 2 (1.7) | 24 (12.4) |
1
NAFLD, nonalcoholic fatty liver disease.