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. 2012 Feb;86(4):2221–2228. doi: 10.1128/JVI.06577-11

Fig 2.

Fig 2

HCV core and NS5A proteins inhibit C3 promoter activity. (A) Basal suppression of C3 promoter activity by HCV core and NS5A proteins in a luciferase reporter assay. In contrast, NS2 or NS3/4A did not display a major effect on C3 promoter activity. The results obtained were statistically significantly different (P < 0.0001) from the values of the vector control by an unpaired two-tailed t test. (B) Core and NS5A proteins downregulated C3 promoter activity in a dose-dependent manner (100 ng/well and 200 ng/well; the amount is indicated by the height of the black triangle below the bars). The results obtained were statistically significant (P < 0.0001) from the value of the vector control by an unpaired two-tailed t test. (C) IL-1β- and/or IL-6-mediated induction of C3 promoter activity. Results obtained were statistically significantly different (P < 0.0001) from the uninduced control using one-way ANOVA. (D) HCV core and NS5A proteins also suppressed IL-1β-induced C3 promoter activation.