Table 3.
Responses of CD8+ T cells from individuals infected with 3R virus to WT or 3R peptide
| Patient ID | Virus sequence [mo/day/yr (type)] |
PBMC sampling date (mo/day/yr) | PBMCs cultured with: | % IFN-γ-producing cells specific for each peptide among CD8+ T cellsa |
|||
|---|---|---|---|---|---|---|---|
| Early phase | Chronic phase | Without | WT | 3R | |||
| KI-091 | 12/13/2000 (3R) | 8/4/2005 (3R) | 12/13/2000 | WT | 0.2 | 74.6 | 71.2 |
| 3R | 0.3 | 55.4 | 71.9 | ||||
| 9/29/2004 | WT | 0.2 | 77.7 | 65.5 | |||
| 3R | 0.2 | 61.1 | 69.3 | ||||
| KI-134 | 10/25/2001 (3R) | 6/30/2004 (3R) | 10/25/2001 | WT | 0.4 | 0.6 | 0.8 |
| 3R | 1.0 | 1.1 | 5.7 | ||||
| 1/21/2004 | WT | 0.8 | 1.0 | 0.7 | |||
| 3R | 0.7 | 0.6 | 2.0 | ||||
| KI-136 | 10/29/2001 (3R) | 7/10/2003 (3R) | 10/29/2001 | WT | 0.1 | 0.4 | 0.2 |
| 3R | 0.1 | 0.2 | 0.2 | ||||
| 5/15/2003 | WT | 0.4 | 0.8 | 0.4 | |||
| 3R | 0.1 | 0.2 | 24.8 | ||||
| KI-151 | 2/15/2002 (3R) | 6/16/2005 (3R) | 11/21/2001 | WT | 0.3 | 0.7 | 0.8 |
| 3R | 0.7 | 0.6 | 10.8 | ||||
| 7/28/2004 | WT | 0.4 | 0.7 | 1.3 | |||
| 3R | 0.1 | 0.1 | 44.5 | ||||
| KI-163 | 8/30/2002 (3R) | 9/27/2004 (3R) | 8/30/2002 | WT | 0.2 | 0.3 | 0.2 |
| 3R | 0.2 | 0.4 | 0.2 | ||||
| 8/29/2005 | WT | 0.3 | 0.5 | 0.2 | |||
| 3R | 0.4 | 0.6 | 6.9 | ||||
a
Without, without peptide. Boldface, positive IFN-γ-producing response.