Fig 7.

NR2E1/fierce mouse brains were partially corrected for reduced olfactory bulb and cerebrum size. (A) Gross brain dissection revealed reduced olfactory bulb (OB) and cerebrum size for fierce mice, a known characteristic of the null phenotype. To a lesser extent, NR2E1/fierce mice also displayed these abnormalities, suggesting incomplete correction of the fierce brain phenotype by the human gene. (Scale bar, 5 mm.) (B) Surface quantification revealed significant reduction of the OB in NR2E1/fierce mice compared to that in Wt and NR2E1 mice (∗, P < 0.001). The NR2E1/fierce OB was also significantly bigger than the fierce OB (∗∗, P < 0.01). No significance was found when comparing Wt and NR2E1 mice. (C) Similarly, cerebrum area was significantly reduced in NR2E1/fierce mice compared to that in Wt and NR2E1 mice (∗, P < 0.001). The NR2E1/fierce cerebrum was also significantly bigger than the fierce cerebrum (∗∗, P < 0.001). No significance was found when comparing Wt and NR2E1 mice. (B and C) The Kruskal-Wallis H test was performed on 6 to 10 mice for all genotypes. Error bars represent standard errors of the means.