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Loss of SIRT1 reduces the activity of FXR signaling pathway in primary hepatocytes. (A) SIRT1 deficiency in primary hepatocytes reduces the induction of FXR target genes by GW4064. *, P < 0.05. (B) Overexpression of SIRT1 in primary hepatocytes restores the expression of FXR targets. Primary hepatocytes from control and SIRT1 LKO mice were infected with lentiviruses expressing GFP or SIRT1. The mRNA levels of FXR target genes were analyzed by qPCR. *, P < 0.05.
