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. 2012 Apr;32(7):1226–1236. doi: 10.1128/MCB.05988-11

Fig 5.

Fig 5

Loss of SIRT1 in hepatocytes results in decreased expression of other HNF1α target genes. (A) SIRT1 deficiency in the liver leads to decreased expression of other HNF1α target genes (n = 11). *, P < 0.05. (B) SIRT1 deficiency leads to decreased expression of other HNF1α target genes in primary hepatocytes (n = 3) *, P < 0.05. (C) Overexpression of SIRT1 in SIRT1-deficient primary hepatocytes restores the expression of other HNF1α target genes in primary hepatocytes. *, P < 0.05. MOI = 2.5 and 5, respectively. a-Fetoprotein, α-fetoprotein; a-Fibrinogen, α-fibrinogen.