Fig 2.

Organization of the ComX-regulated loci in S. thermophilus LMD9. The selected set of upregulated genes (red and red-hatched pentagons) is based on the microarray experiment performed on WT LMD-9 versus the LMD-9 comX mutant (loci I to XIII) (see Table S2 in the supplemental material). These genes are organized into 13 loci on the basis of the presence of predicted ComX boxes (arrows with white rectangles) (see Table S3 in the supplemental material). Shared upregulated genes resulting from mecA inactivation and obtained from the microarray experiment with CB0052 (mecA::lox72) versus WT LMD-9 (Table 3) are shown as red-hatched pentagons. Pentagons surrounded by a dotted line and a black line correspond to late and essential late com genes in S. pneumoniae TIGR4, respectively (41). The ORF orientation in each locus is indicated by the direction of the pentagons. The number below each pentagon corresponds to the STER locus tag of LMD-9. Ψ, pseudogene.