Fig 11.

Phylogenetic tree of cellular and viral FGARAT proteins. The amino acid sequences of the respective FGARAT homologs were aligned by use of the Clustal Omega program (35), and an unrooted phylogenetic tree was calculated with ClustalW2 software (21) using the neighbor-joining algorithm to construct trees from the distance matrix after exclusion of gaps and correction for multiple substitutions. The various ORF3, rodent virus ORF75, and other ORF75 cluster to different branches of the phylogenetic tree. EHV2, equine herpesvirus 2; PoLV, porcine lymphocryptovirus; RoHV, rodent herpesvirus Peru; RhLCV, rhesus lymphocryptovirus; CjLCV, Callithrix jacchus lymphocryptovirus; MfRR V, Macaca fuscata rhadinovirus; MmRRV, Macaca mulatta rhadinovirus; Bac16, KSHV Bac16 strain; KSHV, KSHV BC-1 strain.