Table 2.
Comparison of genomic features and amino acid identities among CoVs with complete genome sequences availablea
| CoV | Genome features |
Pairwise amino acid identity (%) |
Pairwise amino acid identity (%) |
||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Size (bases) | G+C content | PorCoV HKU15 |
WECoV HKU16 |
SpCoV HKU17 |
MRCoV HKU18 |
NHCoV HKU19 |
WiCoV HKU20 |
CMCoV HKU21 |
|||||||||||||||||||||||||||||
| 3CLpro | RdRp | Hel | S | N | 3CLpro | RdRp | Hel | S | N | 3CLpro | RdRp | Hel | S | N | 3CLpro | RdRp | Hel | S | N | 3CLpro | RdRp | Hel | S | N | 3CLpro | RdRp | Hel | S | N | 3CLpro | RdRp | Hel | S | N | |||
| Alphacoronavirus | |||||||||||||||||||||||||||||||||||||
| PEDV | 28,033 | 0.42 | 35.8 | 48.7 | 49.3 | 38.0 | 23.4 | 37.4 | 49.3 | 47.8 | 38.7 | 22.4 | 36.5 | 48.9 | 48.9 | 39.2 | 24.1 | 36.8 | 48.9 | 49.1 | 40.8 | 22.3 | 37.2 | 48.8 | 47.9 | 36.3 | 20.6 | 39.7 | 50.0 | 48.5 | 37.9 | 21.1 | 38.1 | 49.6 | 46.7 | 39.4 | 21.7 |
| TGEV | 28,586 | 0.38 | 34.9 | 49.6 | 51.6 | 35.5 | 23.2 | 34.5 | 49.4 | 49.6 | 36.1 | 24.5 | 35.3 | 49.8 | 51.4 | 39.4 | 23.5 | 34.6 | 49.6 | 50.7 | 39.9 | 23.7 | 32.9 | 50.8 | 50.8 | 37.1 | 22.3 | 37.3 | 50.2 | 50.2 | 36.7 | 23.7 | 33.7 | 49.3 | 49.4 | 36.4 | 22.9 |
| FIPV | 29,355 | 0.38 | 35.7 | 49.7 | 51.2 | 35.1 | 24.5 | 35.5 | 49.6 | 49.3 | 36.3 | 25.1 | 35.7 | 49.9 | 51.1 | 38.5 | 25.0 | 35.5 | 50.1 | 50.4 | 38.9 | 22.2 | 32.4 | 51.2 | 50.7 | 36.9 | 20.8 | 37.9 | 50.1 | 50.0 | 36.5 | 22.5 | 34.5 | 49.7 | 49.1 | 36.0 | 22.1 |
| CCoV | 29,363 | 0.38 | 35.6 | 49.7 | 51.6 | 34.9 | 23.3 | 35.2 | 49.4 | 49.6 | 35.6 | 24.0 | 35.9 | 49.8 | 51.4 | 38.8 | 23.3 | 35.3 | 49.6 | 50.7 | 39.3 | 23.0 | 32.9 | 50.8 | 50.7 | 36.4 | 23.6 | 37.3 | 49.9 | 50.7 | 36.3 | 23.7 | 33.3 | 49.1 | 49.4 | 35.2 | 23.4 |
| PRCV | 27,550 | 0.37 | 34.9 | 49.5 | 51.6 | 40.3 | 23.2 | 34.5 | 49.3 | 49.6 | 40.5 | 23.2 | 35.3 | 49.7 | 51.4 | 44.8 | 23.5 | 34.6 | 49.5 | 50.7 | 44.4 | 22.8 | 32.9 | 50.7 | 50.8 | 41.4 | 22.0 | 37.3 | 50.3 | 50.2 | 41.9 | 23.7 | 33.7 | 49.1 | 49.4 | 40.1 | 21.8 |
| HCoV-229E | 27,317 | 0.38 | 34.4 | 49.3 | 50.6 | 42.5 | 21.6 | 35.4 | 49.0 | 48.3 | 42.4 | 22.5 | 34.2 | 49.5 | 50.2 | 45.5 | 23.0 | 34.8 | 49.3 | 49.8 | 44.0 | 22.5 | 34.6 | 49.2 | 49.0 | 39.9 | 20.4 | 36.3 | 49.6 | 49.6 | 44.1 | 21.5 | 34.8 | 48.6 | 47.5 | 43.2 | 22.8 |
| HCoV-NL63 | 27,553 | 0.34 | 35.9 | 48.8 | 49.9 | 38.2 | 22.1 | 38.1 | 49.2 | 48.1 | 40.1 | 23.0 | 35.6 | 49.2 | 49.6 | 39.3 | 22.6 | 36.9 | 49.2 | 49.5 | 39.3 | 24.6 | 34.8 | 48.9 | 49.0 | 36.2 | 21.5 | 39.1 | 50.6 | 48.6 | 38.8 | 23.5 | 36.9 | 49.5 | 47.2 | 38.8 | 20.6 |
| Rh-BatCoV-HKU2 | 27,165 | 0.39 | 34.4 | 50.1 | 51.4 | 25.0 | 20.8 | 34.3 | 50.0 | 49.1 | 25.2 | 22.3 | 34.4 | 50.2 | 51.1 | 26.2 | 20.9 | 34.4 | 49.8 | 50.3 | 25.9 | 21.7 | 34.3 | 50.5 | 49.7 | 25.1 | 20.9 | 35.5 | 50.6 | 49.1 | 26.3 | 25.2 | 34.1 | 50.1 | 49.1 | 27.3 | 22.5 |
| Mi-BatCoV 1A | 28,326 | 0.38 | 33.5 | 49.0 | 51.4 | 35.8 | 24.4 | 35.0 | 49.4 | 50.1 | 35.7 | 23.3 | 34.2 | 49.4 | 51.1 | 39.4 | 25.2 | 34.2 | 49.0 | 51.4 | 38.2 | 24.5 | 32.6 | 50.5 | 48.7 | 35.7 | 23.8 | 34.7 | 49.9 | 48.9 | 36.4 | 22.5 | 33.4 | 47.9 | 49.1 | 38.6 | 22.4 |
| Mi-BatCoV 1B | 28,476 | 0.39 | 34.2 | 48.5 | 51.1 | 35.6 | 24.6 | 35.4 | 48.8 | 49.4 | 36.1 | 22.1 | 34.8 | 48.8 | 50.7 | 39.1 | 24.9 | 33.5 | 48.8 | 51.1 | 38.2 | 23.8 | 31.9 | 49.8 | 48.2 | 35.7 | 22.3 | 35.7 | 49.6 | 48.9 | 35.7 | 24.1 | 32.8 | 47.7 | 48.3 | 38.2 | 22.8 |
| Mi-BatCoV-HKU8 | 28,773 | 0.42 | 33.1 | 49.3 | 49.8 | 35.9 | 19.4 | 36.0 | 49.9 | 47.5 | 36.0 | 18.8 | 33.4 | 49.6 | 49.3 | 38.9 | 20.4 | 34.4 | 49.3 | 49.3 | 40.4 | 19.8 | 34.6 | 50.1 | 48.1 | 37.2 | 22.6 | 36.7 | 50.5 | 48.8 | 37.6 | 22.3 | 36.0 | 48.5 | 47.4 | 37.0 | 21.6 |
| Sc-BatCoV-512 | 28,179 | 0.40 | 33.8 | 48.6 | 49.1 | 39.0 | 24.8 | 36.0 | 49.2 | 47.5 | 38.7 | 23.7 | 34.1 | 48.7 | 48.8 | 41.3 | 25.2 | 35.4 | 48.3 | 48.8 | 41.1 | 23.4 | 34.9 | 49.0 | 47.8 | 36.8 | 22.3 | 37.3 | 48.9 | 49.1 | 38.1 | 23.1 | 34.7 | 48.7 | 47.8 | 39.6 | 24.3 |
| Betacoronavirus | |||||||||||||||||||||||||||||||||||||
| Subgroup A | |||||||||||||||||||||||||||||||||||||
| HCoV-OC43 | 30,738 | 0.37 | 38.1 | 51.6 | 48.3 | 26.0 | 22.2 | 38.9 | 51.5 | 48.6 | 25.9 | 23.2 | 37.8 | 51.8 | 48.3 | 26.9 | 22.4 | 37.5 | 51.3 | 48.3 | 26.4 | 21.0 | 34.1 | 54.5 | 48.4 | 25.9 | 22.5 | 38.7 | 51.8 | 48.4 | 25.7 | 20.4 | 37.8 | 51.5 | 49.0 | 25.6 | 24.2 |
| BCoV | 31,028 | 0.37 | 38.5 | 51.8 | 48.4 | 25.7 | 22.9 | 38.8 | 51.7 | 48.6 | 25.8 | 21.7 | 38.5 | 51.8 | 48.4 | 26.7 | 22.8 | 37.8 | 51.5 | 48.4 | 26.9 | 24.0 | 34.4 | 54.5 | 48.5 | 25.6 | 23.4 | 38.3 | 51.7 | 48.5 | 26.0 | 21.5 | 38.2 | 51.6 | 49.0 | 25.7 | 23.4 |
| PHEV | 30,480 | 0.37 | 38.5 | 51.7 | 48.3 | 26.9 | 22.1 | 38.1 | 51.6 | 48.6 | 26.1 | 23.1 | 38.5 | 51.6 | 48.3 | 27.2 | 22.3 | 37.8 | 51.4 | 48.3 | 26.9 | 22.2 | 34.4 | 54.5 | 48.5 | 26.1 | 22.7 | 38.7 | 51.7 | 48.5 | 27.1 | 21.6 | 38.2 | 51.6 | 49.0 | 25.4 | 24.1 |
| AntelopeCoV | 30,995 | 0.37 | 38.5 | 51.8 | 48.4 | 25.8 | 22.9 | 38.8 | 51.7 | 48.5 | 25.6 | 21.7 | 38.5 | 51.8 | 48.4 | 27.0 | 22.1 | 37.8 | 51.4 | 48.4 | 27.0 | 24.0 | 34.4 | 54.4 | 48.5 | 26.1 | 23.9 | 38.3 | 51.7 | 48.5 | 26.2 | 21.5 | 38.2 | 51.6 | 49.2 | 25.8 | 23.4 |
| GiCoV | 30,979 | 0.37 | 38.8 | 51.8 | 48.4 | 25.9 | 22.9 | 38.8 | 51.7 | 48.5 | 25.7 | 21.7 | 38.8 | 51.8 | 48.4 | 27.2 | 22.1 | 37.8 | 51.4 | 48.4 | 27.0 | 24.0 | 34.4 | 54.4 | 48.5 | 25.7 | 23.9 | 38.3 | 51.7 | 48.5 | 26.5 | 21.5 | 38.5 | 51.6 | 49.2 | 25.9 | 23.4 |
| ECoV | 30,992 | 0.37 | 38.5 | 51.7 | 49.8 | 26.0 | 23.9 | 38.8 | 51.6 | 49.0 | 26.4 | 22.6 | 38.5 | 51.7 | 49.9 | 26.5 | 24.0 | 37.8 | 51.4 | 49.8 | 27.5 | 23.5 | 34.4 | 54.6 | 48.5 | 25.3 | 24.6 | 38.3 | 51.5 | 48.5 | 26.9 | 22.0 | 38.2 | 51.6 | 49.7 | 25.6 | 24.9 |
| MHV | 31,357 | 0.42 | 38.3 | 51.9 | 48.1 | 26.3 | 24.3 | 39.0 | 51.3 | 48.5 | 26.1 | 24.0 | 38.3 | 51.8 | 48.3 | 26.5 | 25.3 | 37.6 | 51.9 | 48.3 | 26.3 | 24.2 | 35.0 | 53.6 | 47.5 | 25.3 | 24.6 | 39.6 | 50.8 | 47.9 | 27.1 | 24.0 | 39.2 | 51.2 | 48.6 | 26.0 | 24.6 |
| HCoV-HKU1 | 29,926 | 0.32 | 38.1 | 51.2 | 49.3 | 26.1 | 25.2 | 38.0 | 51.4 | 48.2 | 26.4 | 24.8 | 37.9 | 51.3 | 49.4 | 25.7 | 26.0 | 36.4 | 51.4 | 48.8 | 26.4 | 26.0 | 36.3 | 54.4 | 47.4 | 25.4 | 24.7 | 38.1 | 50.9 | 48.5 | 25.8 | 22.7 | 38.3 | 51.2 | 47.8 | 25.0 | 25.4 |
| RCoV | 31,250 | 0.41 | 38.7 | 51.8 | 47.9 | 27.2 | 24.5 | 39.5 | 51.4 | 48.3 | 27.0 | 24.3 | 38.5 | 51.7 | 48.1 | 25.5 | 25.1 | 38.2 | 51.8 | 48.2 | 25.8 | 25.0 | 35.0 | 53.6 | 47.4 | 24.3 | 25.2 | 39.9 | 50.7 | 47.7 | 27.4 | 24.1 | 38.3 | 51.0 | 48.4 | 26.4 | 23.5 |
| Subgroup B | |||||||||||||||||||||||||||||||||||||
| SARS CoV | 29,751 | 0.41 | 34.5 | 50.7 | 51.4 | 26.1 | 26.5 | 36.1 | 50.3 | 50.6 | 27.9 | 24.7 | 34.2 | 51.1 | 51.6 | 25.3 | 25.6 | 34.2 | 50.8 | 51.4 | 25.4 | 26.2 | 32.1 | 50.5 | 50.2 | 26.3 | 22.7 | 34.8 | 49.8 | 50.3 | 26.9 | 24.3 | 32.9 | 50.8 | 51.0 | 27.3 | 24.8 |
| SARSr-CiCoV | 29,728 | 0.41 | 34.5 | 50.7 | 51.4 | 26.2 | 26.5 | 36.1 | 50.3 | 50.6 | 28.0 | 24.7 | 34.2 | 51.1 | 51.6 | 25.2 | 25.6 | 34.2 | 50.8 | 51.4 | 25.5 | 26.2 | 32.1 | 50.5 | 50.2 | 26.2 | 22.7 | 34.8 | 49.8 | 50.3 | 27.0 | 24.3 | 32.9 | 50.8 | 51.0 | 27.1 | 24.8 |
| SARSr-Rh-BatCoV HKU3 | 29,704 | 0.41 | 34.2 | 50.5 | 51.4 | 26.4 | 25.2 | 35.8 | 50.3 | 50.8 | 26.2 | 24.3 | 33.9 | 51.1 | 51.6 | 25.6 | 24.9 | 33.9 | 50.9 | 51.4 | 26.0 | 25.7 | 32.1 | 50.4 | 50.6 | 25.6 | 23.0 | 34.8 | 49.7 | 50.5 | 26.0 | 23.5 | 32.6 | 50.6 | 51.3 | 27.2 | 24.1 |
| SARSr CoV CFB | 29,734 | 0.41 | 34.5 | 50.6 | 51.4 | 26.1 | 26.5 | 36.1 | 50.2 | 50.6 | 28.0 | 24.7 | 34.2 | 51.0 | 51.6 | 25.5 | 25.6 | 34.2 | 50.7 | 51.4 | 25.2 | 26.2 | 32.1 | 50.4 | 50.2 | 25.9 | 22.7 | 34.8 | 49.9 | 50.3 | 26.8 | 24.3 | 32.9 | 50.7 | 51.0 | 27.2 | 24.8 |
| Subgroup C | |||||||||||||||||||||||||||||||||||||
| Ty-BatCoV-HKU4 | 30,286 | 0.38 | 36.9 | 51.2 | 49.8 | 26.6 | 25.1 | 36.6 | 51.0 | 49.4 | 26.1 | 24.7 | 36.9 | 51.5 | 49.7 | 27.0 | 26.2 | 35.7 | 51.0 | 49.7 | 27.3 | 25.9 | 32.7 | 51.3 | 49.9 | 27.3 | 24.4 | 35.8 | 50.9 | 49.9 | 26.4 | 24.4 | 35.6 | 51.9 | 48.9 | 26.8 | 25.1 |
| Pi-BatCoV-HKU5 | 30,488 | 0.43 | 35.7 | 51.1 | 50.0 | 26.0 | 25.6 | 37.8 | 50.3 | 49.0 | 25.5 | 25.7 | 35.4 | 51.4 | 49.8 | 27.2 | 25.3 | 35.0 | 51.1 | 49.7 | 26.3 | 26.2 | 33.7 | 50.9 | 49.6 | 26.2 | 25.6 | 34.6 | 51.2 | 49.8 | 25.3 | 24.7 | 36.0 | 50.9 | 49.0 | 25.7 | 26.1 |
| Subgroup D | |||||||||||||||||||||||||||||||||||||
| Ro-Bat-CoV HKU9 | 29,114 | 0.41 | 36.4 | 51.6 | 51.2 | 28.4 | 25.1 | 39.2 | 52.6 | 50.1 | 26.5 | 23.1 | 36.4 | 51.7 | 50.9 | 26.6 | 24.9 | 35.8 | 51.9 | 50.9 | 27.7 | 25.0 | 33.8 | 52.2 | 50.9 | 27.0 | 22.8 | 35.0 | 51.4 | 49.2 | 27.2 | 22.9 | 36.9 | 52.3 | 51.4 | 27.8 | 23.3 |
| Gammacoronavirus | |||||||||||||||||||||||||||||||||||||
| IBV | 27,608 | 0.38 | 43.9 | 54.8 | 56.6 | 30.3 | 30.0 | 42.6 | 54.6 | 54.5 | 29.9 | 30.8 | 44.2 | 54.9 | 56.6 | 27.6 | 28.9 | 43.3 | 54.3 | 56.2 | 28.4 | 30.3 | 43.6 | 53.6 | 54.8 | 28.7 | 29.7 | 47.1 | 52.4 | 55.4 | 29.4 | 29.2 | 41.7 | 53.9 | 55.1 | 29.4 | 28.1 |
| TCoV | 27,657 | 0.38 | 43.6 | 54.9 | 57.1 | 30.1 | 29.2 | 43.3 | 54.5 | 55.3 | 30.3 | 29.6 | 43.9 | 55.0 | 57.1 | 29.5 | 29.5 | 42.3 | 54.4 | 57.1 | 30.3 | 29.2 | 44.3 | 53.8 | 55.3 | 30.3 | 30.0 | 46.2 | 52.8 | 55.4 | 30.3 | 29.9 | 41.3 | 53.6 | 55.8 | 30.6 | 28.2 |
| BWCoV-SW1 | 31,686 | 0.39 | 38.8 | 52.9 | 52.8 | 27.1 | 32.1 | 39.5 | 52.9 | 51.6 | 28.3 | 31.1 | 38.8 | 52.9 | 52.8 | 28.5 | 31.9 | 37.2 | 52.3 | 52.2 | 27.3 | 31.6 | 41.1 | 52.8 | 54.2 | 27.4 | 30.2 | 42.0 | 52.2 | 51.1 | 27.2 | 30.0 | 38.8 | 52.1 | 52.7 | 28.2 | 31.5 |
| Deltacoronavirus | |||||||||||||||||||||||||||||||||||||
| BuCoV HKU11 | 26,476 | 0.39 | 81.1 | 88.2 | 89.4 | 69.8 | 74.8 | 82.4 | 90.9 | 96.0 | 62.5 | 73.2 | 80.8 | 88.2 | 89.6 | 43.5 | 75.1 | 79.5 | 88.3 | 90.4 | 44.5 | 71.9 | 57.0 | 72.3 | 76.8 | 41.1 | 50.6 | 58.3 | 70.8 | 75.4 | 43.3 | 51.4 | 77.5 | 84.8 | 91.0 | 51.8 | 60.7 |
| ThCoV HKU12 | 26,396 | 0.38 | 82.1 | 88.2 | 89.7 | 47.9 | 79.7 | 83.1 | 89.5 | 94.7 | 47.8 | 81.0 | 81.8 | 88.2 | 89.9 | 46.7 | 79.4 | 81.4 | 86.8 | 89.9 | 45.8 | 76.7 | 57.3 | 71.9 | 76.4 | 43.6 | 49.4 | 57.7 | 71.3 | 74.5 | 43.6 | 49.6 | 78.2 | 84.4 | 90.5 | 46.2 | 63.3 |
| MunCoV HKU13 | 26,552 | 0.43 | 82.7 | 90.1 | 95.8 | 71.2 | 76.8 | 76.5 | 87.9 | 89.1 | 61.3 | 74.6 | 83.4 | 90.1 | 96.0 | 43.8 | 78.8 | 94.5 | 94.6 | 98.0 | 46.1 | 87.5 | 53.1 | 72.9 | 78.0 | 41.4 | 53.4 | 55.4 | 71.7 | 75.7 | 44.0 | 53.2 | 72.0 | 84.7 | 85.4 | 52.2 | 64.4 |
| PorCoV HKU15 | 25,421 | 0.43 | 76.9 | 88.1 | 88.4 | 61.9 | 75.8 | 97.0 | 97.8 | 99.2 | 44.8 | 96.8 | 84.3 | 90.6 | 96.1 | 44.4 | 77.9 | 54.0 | 72.5 | 78.2 | 41.8 | 52.2 | 57.7 | 71.0 | 74.9 | 43.8 | 52.4 | 73.6 | 84.5 | 84.6 | 50.1 | 62.0 | |||||
| WECoV HKU16 | 26,027 | 0.40 | 76.9 | 88.1 | 88.4 | 61.9 | 75.8 | 77.2 | 88.3 | 88.6 | 46.4 | 76.4 | 77.2 | 87.3 | 89.1 | 45.5 | 75.4 | 55.0 | 71.7 | 76.6 | 42.1 | 49.6 | 59.6 | 71.5 | 74.3 | 43.4 | 50.6 | 76.9 | 84.8 | 90.5 | 51.5 | 64.3 | |||||
| SpCoV HKU17 | 26,067 | 0.45 | 97.0 | 97.8 | 99.2 | 44.8 | 96.8 | 77.2 | 88.3 | 88.6 | 46.4 | 76.4 | 84.9 | 91.0 | 96.3 | 68.1 | 79.0 | 52.8 | 72.3 | 78.4 | 47.2 | 51.9 | 58.0 | 71.0 | 75.1 | 45.8 | 53.2 | 73.0 | 84.7 | 84.9 | 46.0 | 63.5 | |||||
| MRCoV HKU18 | 26,674 | 0.47 | 84.3 | 90.6 | 96.1 | 44.4 | 77.9 | 77.2 | 87.3 | 89.1 | 45.5 | 75.4 | 84.9 | 91.0 | 96.3 | 68.1 | 79.0 | 54.0 | 72.5 | 77.7 | 46.4 | 53.8 | 56.4 | 71.2 | 75.1 | 46.3 | 53.1 | 73.3 | 85.1 | 84.8 | 45.7 | 63.9 | |||||
| NHCoV HKU19 | 26,064 | 0.38 | 54.0 | 72.5 | 78.2 | 41.8 | 52.2 | 55.0 | 71.7 | 76.6 | 42.1 | 49.6 | 52.8 | 72.3 | 78.4 | 47.2 | 51.9 | 54.0 | 72.5 | 77.7 | 46.4 | 53.8 | 58.3 | 69.3 | 75.4 | 41.0 | 54.5 | 55.5 | 71.9 | 77.6 | 43.6 | 54.5 | |||||
| WiCoV HKU20 | 26,211 | 0.39 | 57.7 | 71.0 | 74.9 | 43.8 | 52.4 | 59.6 | 71.5 | 74.3 | 43.4 | 50.6 | 58.0 | 71.0 | 75.1 | 45.8 | 53.2 | 56.4 | 71.2 | 75.1 | 46.3 | 53.1 | 58.3 | 69.3 | 75.4 | 41.0 | 54.5 | 58.3 | 70.8 | 76.4 | 44.1 | 57.0 | |||||
| CMCoV HKU21 | 26,216 | 0.35 | 73.6 | 84.5 | 84.6 | 50.1 | 62.0 | 76.9 | 84.8 | 90.5 | 51.5 | 64.3 | 73.0 | 84.7 | 84.9 | 46.0 | 63.5 | 73.3 | 85.1 | 84.8 | 45.7 | 63.9 | 55.5 | 71.9 | 77.6 | 43.6 | 54.5 | 58.3 | 70.8 | 76.4 | 44.1 | 57.0 | |||||
a
Comparison of genomic features of PorCoV HKU15, WECoV HKU16, SpCoV HKU17, MRCoV HKU18, NHCoV HKU19, WiCoV HKU20, and CMCoV HKU21 and other CoVs with complete genome sequences available and of amino acid identities between the predicted 3CLpro, RNA-dependent RNA (RdRp), helicase (Hel), S, and N proteins of PorCoV HKU15, WECoV HKU16, SpCoV HKU17, MRCoV HKU18, NHCoV HKU19, WiCoV HKU20, and CMCoV HKU21 and the corresponding proteins of other CoVs. PEDV, porcine epidemic diarrhea virus; TGEV, porcine transmissible gastroenteritis virus; FIPV, feline infectious peritonitis virus; CCoV, canine coronavirus; PRCV, porcine respiratory coronavirus; HCoV-229E, human coronavirus 229E; HCoV-NL63, human coronavirus NL63; Rh-BatCoV-HKU2, Rhinolophus bat coronavirus HKU2; Mi-BatCoV 1A, Miniopterus bat coronavirus 1A; Mi-BatCoV 1B, Miniopterus bat coronavirus 1B; Mi-BatCoV-HKU8, Miniopterus bat coronavirus HKU8; Sc-BatCoV-512, Scotophilus bat coronavirus 512; HCoV OC43, human coronavirus OC43; BCoV, bovine coronavirus; PHEV, porcine hemagglutinating encephalomyelitis virus; AntelopeCoV, sable antelope coronavirus; GiCoV, giraffe coronavirus; ECoV, equine coronavirus; MHV, murine hepatitis virus; HCoV-HKU1, human coronavirus HKU1; RCoV, rat coronavirus; SARS CoV, SARS-related human coronavirus; SARSr-CiCoV, SARS-related palm civet coronavirus; SARSr-Rh-BatCoV HKU3, SARS-related Rhinolophus bat coronavirus HKU3; SARSr CoV CFB, SARS-related Chinese ferret badger coronavirus; Ty-BatCoV-HKU4, Tylonycteris bat coronavirus HKU4; Pi-BatCoV-HKU5, Pipistrellus bat coronavirus HKU5; Ro-BatCoV-HKU9, Rousettus bat coronavirus HKU9; IBV, infectious bronchitis virus; TCoV, turkey coronavirus; BWCoV-SW1, Beluga whale coronavirus SW1; BuCoV HKU11, bulbul coronavirus HKU11; ThCoV HKU12, thrush coronavirus HKU12; MunCoV HKU13, munia coronavirus HKU13.