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Corrected versus uncorrected picornavirus-wide pairwise distances. Plotted is corrected pairwise evolutionary distance (PED) versus pairwise uncorrected distance (PUD) for the M-2010 data set. For intermediate and large distances, a saturation of PUD values is observed, as they do not account for the total amount of evolutionary work happened, e.g., for multiple substitutions at the same sequence position. Points on the dashed line (diagonal) have equal PED and PUD values.
