Table 1.
Gross pathology in ferrets inoculated with H5N1WT virus or H5N1ΔMBCS virus
| Virus | dpi | Animals with macroscopic lung lesionsa | Area of lung affected (%)b | Relative lung wt (%) | Empty stomachc |
|---|---|---|---|---|---|
| H5N1WT | 1 | 1/3 | 2 ± 3 | 0.7 ± 0.0 | 1/3 |
| 3 | 2/3 | 3 ± 3 | 0.7 ± 0.0 | 3/3 | |
| 5 | 3/3 | 29 ± 23 | 1.3 ± 0.4 | 3/3 | |
| 7 | 3/3 | 37 ± 39 | 1.3 ± 0.7 | 3/3 | |
| H5N1ΔMBCS | 1 | 2/3 | 3 ± 3 | 0.8 ± 0.1 | 1/3 |
| 3 | 2/3 | 5 ± 5 | 0.8 ± 0.2 | 1/3 | |
| 5 | 1/3 | 2 ± 3 | 1.0 ± 0.4 | 0/3 | |
| 7 | 2/3 | 7 ± 6 | 0.8 ± 0.1 | 0/3 |
a
Number of ferrets in which macroscopic lung lesions were detected/total number of ferrets are depicted.
b
Area of lung affected and relative lung weight are reported as means ± standard deviations (n = 3).
c
Number of ferrets with empty stomachs/total number of ferrets are depicted.