Table 3.
Detection of influenza A virus nucleoprotein in tissues from ferrets inoculated with either H5N1WT virus or H5N1ΔMBCS virus
| Tissue | H5N1WT |
H5N1ΔMBCS |
||||||
|---|---|---|---|---|---|---|---|---|
| Day 1 | Day 3 | Day 5 | Day 7 | Day 1 | Day 3 | Day 5 | Day 7 | |
| Respiratory system | ||||||||
| Respiratory epithelium | +/− (3/3)a | +/− (3/3)b | +/− (3/3)b | −c | +/− (2/3) | +/− (1/3)b | − | − |
| Olfactory epithelium | +/− (3/3) | + (3/3)b,d | + (3/3)b | + (3/3)b | +/− (2/3) | + (3/3)b | +/− (2/3)b | + (2/3) |
| Trachea | − | − | − | +/− (1/3) | − | − | +/− (2/3)b | − |
| Bronchus | − | − | − | +/− (1/3)b | − | − | − | − |
| Bronchioles | − | − | + (1/3)b | + (1/3)b | − | − | +/− (1/3)b | − |
| Alveoli | − | + (1/3)b | + (3/3)b | − | − | + (1/3)b | + (1/3)b | − |
| Nervous system | ||||||||
| Olfactory bulb | − | + (1/3)b | + (2/3)b | + (3/3)b | − | − | − | − |
| Cerebrum | − | − | + (1/3)b | + (2/3)b | − | − | − | − |
| Cerebellum | − | − | − | + (1/3)b | − | − | − | − |
| Spinal cord | − | − | − | + (1/3)b | − | − | − | − |
| Trigeminal nerve | − | − | + (1/3)b | − | − | − | − | − |
| Other | ||||||||
| Pancreas | − | − | − | + (1/3)b | − | − | − | − |
| Liver | − | − | − | + (2/3)b | − | − | − | − |
| Tonsils | − | + (1/1)b,e | + (1/3)b | − | − | − | − | − |
a
+/−, <10 cells contained virus antigen.
b
The detection of virus antigen was associated with histological lesions.
c
−, virus antigen was not detected.
d
+, >10 cells contained virus antigen.
e
Only one tonsil was sampled.