Table 1.
Clinical observations following VZV inoculation
| Factor | Presence of factor by animal and inoculation regimena |
|||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Group 1 |
Group 2 |
Controls |
||||||||||||||||||
| C88-117M |
C87-009M |
C91-080M |
C04-019M |
C89-100M |
C95-073M |
C91-078M |
C04-015M |
C87-103M |
C93-093M |
|||||||||||
| A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | A | B | |
| Pyrexiab | − | − | + | − | − | − | − | − | − | + | − | − | − | − | − | − | − | − | − | − |
| Anorexiac | − | − | − | − | − | + | − | − | − | − | − | + | − | − | − | + | − | + | − | − |
| Lymphadenopathyd | − | − | − | − | + | + | − | − | − | − | − | − | − | − | − | − | − | − | − | − |
| Abnormal stool/urinee | − | − | − | − | − | − | − | − | − | − | − | + | − | − | − | − | − | + | − | − |
| Coryzaf | − | − | + | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − | − |
Animals were monitored daily for food intake, stool consistency, and general well-being. Animals were routinely weighed, examined for external signs of enlarged lymph nodes, and monitored closely for clinical signs of VZV infection, including, but not limited to, vesicular lesions, fever, generalized malaise, and appetite suppression, concurrent to surveillance for secondary infection. A, initial intratracheal inoculation at week 0; B, intravenous inoculation at week 12. Animal C95-073M coughed immediately after receiving the first inoculation (A) and thus did not receive the full dose.
Increased body temperature of ≥38.4°C.
Lack of appetite exceeding 24-h period following general anesthesia.
Lymph nodes of >1 cm in any diameter.
Diarrhea, blood in stool, hematuria, or hematochezia.
Nasal discharge.